- Skin biopsy analysis is a reliable tool for diagnosing small-fiber neuropathy
- Skin biopsy is a safe and painless procedure that allows somatic fibers carrying temperature and pain sensation to be differentiated from autonomic fibers
- Age is a risk factor. Small fiber neuropathy is more commonly seen in people over the age of 65 than in younger individuals. It is also more common among men.
- Loss of intraepidermal nerve fibers correlates with increased severity of neuropathy and a higher risk of developing neuropathic pain
- Skin nerve fibers are able to regenerate, and their regrowth rate could be a marker of early axonal damage in patients at risk of developing peripheral neuropathy
- Skin biopsy can be repeated in close proximity to a previous biopsy in order to assess the progression of neuropathy and the response to neuroprotective treatments and can be used as a measure of outcomes.